Reengineering di un modulo di un sistema ERP: progettazione e sviluppo del prototipo

Il presente lavoro di tesi, svolto presso la Shinteck s.r.l. di Pontedera, illustra la progettazione e lo sviluppo di un prototipo di un'applicazione web che permetta di replicare un applicativo preesistente presso un'azienda che commercializza oli lubrificanti per motori, utilizzando quindi diverse tecnologie rispetto alle attuali, per migliorarne alcuni aspetti e per permettere di spostare alcuni aspetti della gestione dell'azienda sul web. Prima di descrivere la realizzazione del prototipo è stata effettuata un'analisi delle tecnologie disponibili sul mercato per scegliere quelle più opportune. Particolare attenzione è stata posta nella scelta del framework di sviluppo da utilizzare, tramite l'analisi comparativa delle principali opzioni disponibili nell'ambito dello sviluppo in Java

Results of a research regarding the variability of spring depletion curves

Springs, no recharge periods, discharge process, depletion coefficient

Migratory restlessness in shorebirds (Aves, Charadriiformes). A case study by means of accelerometers

The knowledge of individual and environmental parameters affecting stopover length in shorebirds is important for the conservation and management of species and habitats often seriously threatened, such as Mediterranean wetlands. The role of external factors affecting the decision to leave a stopover site is not always easy to study in the field, due to the high number of variables (i.e., atmospheric conditions) potentially involved. Combining both field and laboratory research has proved to be extremely useful in order to identify the main factors affecting stopover length, at least in passerines. Recent studies demonstrated that the amount of migratory restlessness in these species can be considered a good proxy for quantifying the willingness to depart from a refuelling site. Even if shorebirds have proved to be good models for laboratory research, the only papers regarding migratory restlessness in this group concern studies on orientation mechanisms, which are mainly aimed at showing their use of magnetic compass. The present work aims at studying the migratory restlessness in shorebirds and its relation with body conditions and stopover length by using spring migrating Wood sandpiper (Tringa glareola) as a model species. Despite this method proved to be effective in recording Wood sandpipers activity, we failed to found any relationship among their stopover length, body conditions and nocturnal activity. The degree of nocturnal activity was overall low, whereas a peak in activity was registered at sunset. This twilight activity was oriented, and its amount varied significantly according to the amount of available food in captivity. Our results suggested that migratory restlessness in shorebirds might show some peculiar characteristics that would deserve further investigations

Landslide susceptibility analysis exploiting Persistent Scatterers data in the northern coast of Malta

During the last decade a pressing need for more adequate tools to manage the considerable increasing number of hydrogeological emergencies arose among land planning and civil protection authorities. As a consequence, both development and testing of different qualitative and quantitative methods for landslide displacements detection become fundamental in order to provide the best analysis performance in terms of cost-benefit and scientific reliability. Lately quantitative methods to measure deformations of unstable slopes had great advances. In this context, remotely sensed radar techniques, such as PSI (Persistent Scatterers Interferometry), can assist traditional landslide investigations in assessing ground and infrastructure deformations caused by large landslides. The main purpose of this study is exploiting the results of PSI analysis conducted over the Island of Malta to train a Bayesan model for evaluating active landslide susceptibility. This approach has been applied in the NW coast of Malta, where outstanding coastal landslides, such as rock spreads and block slides, have been recognized and mapped. The outcomes of the statistical analysis have been validated through specific field check and GNSS measurements. The results show that the developed susceptibility model predicts an acceptable percentage of landslides and can be considered reliable even if in areas without PSI data

Case Report: SARS-CoV-2 Infection in a Child With Suprasellar Tumor and Hypothalamic-Pituitary Failure

In early 2020, a novel coronavirus leading to potentially death was discovered. Since then, the 2019 coronavirus disease (COVID-19) has spread to become a worldwide pandemic. Beyond the risks strictly related to the infection, concerns have been expressed for the endocrinological impact that COVID-19 may have, especially in vulnerable individuals with pre-existing endocrinological health conditions. To date new information is emerging regarding severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) in children but the literature is still scarce concerning this infection in patients with intracranial malignant neoplasms. We report a 9-year-old child infected with SARS-CoV-2 and recent diagnosis of suprasellar non-germinomatous germ cell tumor also suffering from diabetes insipidus and hypothalamic-pituitary failure (hypothyroidism, adrenal insufficiency, hypothalamic obesity and growth hormone deficiency) and its clinical course. The patient remained asymptomatic for the duration of the infection without requiring any change in the replacement therapeutic dosages taken before the infection. We then discuss the proposed approach to treat a pediatric patient with SARS-CoV-2 infection and hypothalamic-pituitary failure and we include a review of the literature. Our report suggests that SARS-CoV-2 infection is usually mild and self-limiting in children even those immunocompromised and with multiple endocrinological deficits. Patients are advised to keep any scheduled appointments unless informed otherwise

Quantum characterization of superconducting photon counters

We address the quantum characterization of photon counters based on transition-edge sensors (TESs) and present the first experimental tomography of the positive operator-valued measure (POVM) of a TES. We provide the reliable tomographic reconstruction of the POVM elements up to 11 detected photons and M=100 incoming photons, demonstrating that it is a linear detector.Comment: 3 figures, NJP (to appear

The Little Book of Plastics in Everyday Life

What this Little Book tells you The purpose of this Little Book is to provide a holistic but condensed overview of the key aspects of plastics as they are produced, consumed and disposed of in contemporary consumer culture. We centre attention not just on the materiality of plastics but also on their meanings and how they come to be experienced and lived with in daily life

PIK3CA Mutation in the ShortHER Randomized Adjuvant Trial for Patients with Early HER2\ufe Breast Cancer: Association with Prognosis and Integration with PAM50 Subtype.

Purpose: We explored the prognostic effect of PIK3CA mutation in HER2\ufe patients enrolled in the ShortHER trial. Patients and Methods: The ShortHER trial randomized 1,253 patients with HER2\ufe breast cancer to 9 weeks or 1 year of adjuvant trastuzumab combined with chemotherapy. PIK3CA hotspot mutations in exon 9 and 20 were analyzed by pyrosequencing. Expression of 60 genes, including PAM50 genes was measured using the nCounter platform. Results: A mutation of the PIK3CA gene was detected in 21.7% of the 803 genotyped tumors. At a median follow-up of 7.7 years, 5-year disease-free survival (DFS) rates were 90.6% for PIK3CA mutated and 86.2% for PIK3CA wild-type tumors [HR, 0.84; 95% confidence interval (CI), 0.56\u20131.27; P \ubc 0.417]. PIK3CA mutation showed a favorable prognostic impact in the PAM50 HER2-enriched subtype (n \ubc 232): 5-year DFS 91.8% versus 76.1% (log-rank P \ubc 0.049; HR, 0.46; 95% CI, 0.21\u20131.02). HER2-enriched/PIK3CA mutated versus wild-type tumors showed numerically higher tumor-infiltrating lymphocytes (TIL) and significant upregulation of immune-related genes (including CD8A, CD274, PDCD1, and MYBL2, a proliferation gene involved in immune processes). High TILs as well as the upregulation of PDCD1 and MYBL2 were associated with a significant DFS improvement within the HER2-enriched subtype (HR, 0.82; 95% CI, 0.68\u20130.99; P \ubc 0.039 for 10% TILs increment; HR, 0.81; 95% CI, 0.65\u20130.99; P \ubc 0.049 for PDCD1 expression; HR, 0.72; 95% CI, 0.53\u20130.99; P \ubc 0.042 for MYBL2 expression). Conclusions: PIK3CA mutation showed no prognostic impact in the ShortHER trial. Within the HER2-enriched molecular subtype, patients with PIK3CA mutated tumors showed better DFS versus PIK3CA wild-type, which may be partly explained by upregulation of immune-related genes

Castel di Sangro-Scontrone field camp – structural and applied geomorphology

The Geomorphological Field Camp 2014 in the Castel di Sangro-Scontrone area is the result of geological and geomorphological teaching field work activities carried out in Central Italy by a group of 23 students attending the Structural Geomorphology and Applied Geomorphology courses (Master's Degree in Geological Science and Technology of the Università degli Studi ‘G. d'Annunzio’ Chieti-Pescara, Italy, Department of Engineering and Geology). The Field Camp 2014 was organized in May 2014, following regular classes held during the fall term. General activities for the field camp were developed over four main stages: (1) preliminary analysis of the regional geological and geomorphological setting of the area; (2) preliminary activities for the analysis of the local area (orography, hydrography and photogeology investigations, and geographical information system processing); (3) field work, focused on the analysis of a specific issue concerning structural geomorphology or applied geomorphology (e.g. landscape evolution, river channel change, landslide distribution, and flood hazard); and (4) post-field work production of the map. Finally, the fundamental role of field work in the analysis of landscape and in land management was outlined: indeed, the overall field camp enhanced the crucial role of field-based learning for young geomorphologists in order to acquire a strong sensitivity to geomorphological processes and landscape evolution